REGION G is also known as the Deep South and forms the extreme southern boundary of Johannesburg.

The region was founded for two main reasons. The first was the apartheid legislation that created an Indian residential area in the northern part of the region, known as Lenasia.

The second was the influx of large numbers of people seeking work, resulting in the spontaneous development of informal settlements, especially in the south. As a result, Region G has two fairly distinct areas and is divided for developmental purposes into the Greater Ennerdale, Lenasia, Eldorado Park and Protea areas in the north, and the Orange Farm and Weilers Farm (Kanana Park) area in the south.

Geographically displaced from the rest of greater Johannesburg, it is largely a marginalised dormitory residential area. With no economic base of its own, it is dependent on Johannesburg and, to a lesser extent, on Vanderbijl Park and Vereeniging. Because of the region's distance from the central business districts of Johannesburg and Sandton, public transport is expensive.

Although the northern part of the region does feature some attractive housing and relatively stable communities, as a whole this far-flung region has perhaps suffered more from the legacy of the past than any other. The goal for the future, in the words of the City council's vision statement, is to turn it into "an integral part of Greater Johannesburg, a viable and sustainable environment".